Team led by Houston Methodist addresses need for quick, easy tests to screen plasma donors.
A new study released by Houston Methodist takes researchers a significant step closer to developing a uniform, universal COVID-19 antibody test. The multicenter collaboration tested alternative ways to measure COVID-19 antibody levels that is faster and easier and can inexpensively be used on a larger scale to accurately identify potential donors with the best chance of helping patients infected with the SARS-CoV-2 virus with convalescent plasma therapy.
The findings will also have applications beyond determining who the best plasma donors are. The consensus among the study authors is that, following donor identification, it will most likely next be used in practice to establish target levels of COVID-19 antibodies needed for effective vaccine candidates and passive immune therapies.
Additional uses coming later that are likely to have the biggest societal impact, the researchers say, are to assess relative immunity in those previously infected by the SARS-CoV-2 virus and identifying asymptomatic individuals with high levels of neutralizing antibodies against SARS-CoV-2.
It was also found that donors who experienced shortness of breath (or dyspnea) while infected with COVID-19 and those who were hospitalized or had severe disease were more likely to have a robust immune response and, thus, had higher levels of neutralizing antibodies in all the tests. In the absence of available testing, identifying such donor characteristics may be used as a contingency plan to determine which patients have developed higher antibody levels and inform efforts to recruit plasma donors for therapeutic purposes.Original Source