A team of researchers at the Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI) explains why some people are more susceptible to the effects of the virus, developing the severe disease than others. In some people who contract the virus they develop only mild to moderate symptoms, while some have no symptoms at all.
In the new study, published in the journal Cell, the team has found that the uncoordinated responses produced by the immune system, especially in people who are more than 65 years old, maybe the reason why older adults are more at risk.
The power of the immune system to work properly and in a coordinated manner is critical in fighting the SARS-CoV-2 infection early in the acute phase of the infection. This way, COVID-19 severity will be reduced, preventing the development of severe disease and mortality.
In the study, the researchers noted that the T cells or T lymphocytes, which are one of the significant components of the adaptive immune system, play a more prominent role in the response against the coronavirus than antibodies. T cells work by killing infected host cells and activating other immune cells, producing cytokines, and controlling the immune response.Original Source